Evaluation of the Therapeutic Effectiveness of Polymyxin B Versus Colistin in Carbapenem-resistanct Klebsiella pneumoniae-Associated Bacteremia

Md. Jahidul Hasan, Raihan Rabbani, Sitesh C. Bachar

Abstract


Polymyxins are the last resort antibiotics for treating carbapenem-resistance Klebsiella pneumoniae
(CR-Kp)-associated bacteremia. The main aim of this study was to demonstrate the therapeutic effectiveness of
polymyxin B versus colistin in the treatment of CR-Kp-associated Bacteremia. This 12-month long cross-sectional
study was conducted on 54 and 47 patients suffering from CR-Kp-associated Bacteremia, and residing into two
separate groups, they were treated with polymyxin B and colistin, respectively. After 5 day-treatment, the
microbiological eradication rate was found 96.30% (52; n=54) in polymyxin B group and 87.23% (41; n=47) in
colistin group. In the 30-day mortality rate-comparison, 51.03% more death was found in colistin group (34.04 %, n=
47) than the polymyxin B group (16.67 %, n= 54). In this study, Polymyxin B showed superior therapeutic
potentiality with less number of secondary infections and 30-day mortality rate in CR-Kp-associated bacteremia than
colistin.


Keywords


Carbapenem-resistance, Klebsiella pneumoniae, bacteremia, polymyxin B, colistin.

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The Dhaka University Journal of Pharmaceutical Sciences
ISSN 1816-1820 (Print) 1816-1839 (Online)