Evaluation of Antioxidant and Cytotoxic Activities of Aerial Parts of Adiantum capillus-veneris L. Growing in Bangladesh

Suvash Chandra Roy, B. K. Sajeeb, Md. Abdul Muhit, Sitesh C. Bachar

Abstract


The present study evaluated the antioxidant and cytotoxic activities of methanolic extract of aerial
parts of Adiantum capillus-veneris L. and its different solvent fractions. The in vitro antioxidant activity was
assessed by using 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals. The analysis revealed that ethyl acetate soluble
fraction had the highest DPPH radicals scavenging property with IC50 value of 1.05 μg/ml as compared to positive
control ascorbic acid (IC50 = 1.34 μg/ml). In addition, ex vivo cytotoxicity assay of A. capillus-veneris L. extract and
its different fractions were performed against HELA cells line where 5-Fluorouracil was used as positive control.
The result demonstrated that ethyl acetate and n-hexane soluble fractions showed prominent cytotoxicity with IC50
value of 5.68 μg/ml and 17.15 μg/ml, respectively. The study affirmed that superior antioxidant and cytotoxic
activities were shown by ethyl acetate soluble fraction of methanolic extract of aerial parts of A. capillus-veneris L.
growing in Bangladesh which indicate the presence of bioactive phytoconstituents in the extractives.


Keywords


Antioxidant, cytotoxicity, Adiantum capillus-veneris L., fractionation, bioactivity.

Full Text:

PDF

Refbacks

  • There are currently no refbacks.


The Dhaka University Journal of Pharmaceutical Sciences
ISSN 1816-1820 (Print) 1816-1839 (Online)