In vitro Complexation of Olmesartan Medoxomil with Dapagliflozin, Vildagliptin and Metformin

Fahima Aktar, Md. Zakir Sultan, Mohammad A. Rashid

Abstract


Drug-drug interactions have been a serious concern for pharmacokinetics, pharmacodynamics and
pharmacological profiles of therapeutic agents. The aim of this study was to carry out interactions of olmesartan
medoxomil with dapagliflozin, vildagliptin and metformin, which were confirmed by TLC, HPLC and FT-IR. The
newly formed complexes showed characteristic thermochemical properties in differential scanning calorimetry (DSC)
and thermo gravimetric analysis (TGA). In TLC, three spots from the three complexes were found to be different
from their precursor drugs. In HPLC chromatograms, the Rt (retention time) of the pure olmesartan medoxomil,
dapagliflozin, vildagliptin and metformin were found to be different from their respective complexes. The FT-IR
spectra obtained for drug-drug interactions were seen to demonstrate new pattern of peaks compared to pure drugs.
The DSC and TGA thermograms of olmesartan medoxomil, dapagliflozin, vildagliptin and metformin were also
found to be different from their complexes. All these variations from parent compounds indicated the formation of
new complexes.


Keywords


Drug-drug interaction, olmesartan medoxomil, dapagliflozin, vildagliptin, metformin, TLC, HPLC, FTIR, DSC, TGA.

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The Dhaka University Journal of Pharmaceutical Sciences
ISSN 1816-1820 (Print) 1816-1839 (Online)