Interaction of Manganese(II) with Proton Pump Inhibitor at Different pH: A Cyclic Voltammetric Study

R. Biswas, S. Islam, M. S. Rahman, M. A. Haque, M. Abu Hasan, P. K. Bakshi, A. A. Shaik

Abstract


The electrochemistry of Mn2+ at different pH (3.5-4.5) in acetate buffer solution has been investigated, using cyclic voltammetric method at
glassy carbon electrode (GCE). Cyclic voltammograms (CVs) of Mn2+ show two cathodic and an anodic peaks over the entire investigated pH.
The CVs of Mn2+ has also been performed in presence of proton pump inhibitors (PPIs) such as omeprazole, pantoprazole, esomeprazole and
rabeprazole to elucidate the interaction of Mn2+ with the PPIs in acetate buffer solution. At the studied pH, a reasonably strong interaction was
observed between Mn2+ and PPIs at different molar ratio of Mn2+ ion and PPIs. However, maximum interaction has been found at 1:2 molar
ratio of Mn2+ and PPIs. This indicates the most suitable condition for the interaction between Mn2+ and PPIs. These results could allow insight
into the interactions of metal ions with the PPIs.


Keywords


Transition metal ions, Proton pump inhibitors, Cyclic voltammetry, Glassy carbon electrode, Acetate buffer.

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Dhaka University Journal of Science ISSN 1022-2502 (Print) 2408-8528 (Online)