Implementation and Analysis of Physiologically Based Pharmacokinetic (PBPK) Model for Docetaxel in Cancer Chemotherapy

Abstract

Physiologically based pharmacokinetic (PBPK) models represent an important class of dosimetry models that are useful for predicting internal dose at target organs in human body. In this paper, a whole body Docetaxel based PBPK model has been implemented and analyzed. This model shows the variations and distributions of drug concentrations over time at different organs of human body. Higher drug concentration can affect human body with different toxic side effect. This model can help clinicians to measure the concentration of drugs at different organs using computer based simulation and to decide the correct dose for a patient.