Studies of anti-arrhythmic and hypercholesterolemic activities of ayurvedic preparation ‘Lauhasab’ in rat model

Abstract

Lauhasab, an Ayurvedic preparation, is widely used in anemia and cardiovascular
diseases. Despite its claim as a cardio-tonic there is paucity of studies on pharmacological activities and
toxicities. In this study, the anti-arrhythmic effect and impact on lipid profile were evaluated. Rats were
pretreated with 0.28 and 2.8 ml/kg body weight of Lauhasab for 35 days and electrocardiographic
tracings were recorded and analyzed to determine heart rate and occurrence of arrhythmia.
Electrocardiogram recorded before digoxin administration showed significant decrease in mean heart
rate along with longer duration of bradycardia than in digoxin control group after 35 days of chronic
pretreatment with both doses of Lauhasab. In animal experiments, various arrhythmias were observed
after intraperitoneal injection of digoxin. Lauhasab decreased the duration and delayed onset of time of
various arrhythmias. It showed significant increase in cholesterol and triglyceride levels in a dose
dependent manner. It can be concluded that Lauhasab possesses significant anti-arrhythmic activity
against digoxin-induced arrhythmia. It also revealed hyperlipidemic effects.