Fluorescence spectroscopic studies of in vitro interactions of famotidine and tapentadol hydrochloride with bovine serum albumin

Authors

  • Md. Rasal Hossain Khan
  • Asma Rahman
  • Md. Zakir Sultan
  • Md. Zamil Sultan
  • Mohammad A. Rashid

Keywords:

Famotidine, Tapentadol Hydrochloride, in vitro, bovine serum albumin, fluorescence, spectroscopy

Abstract

The in vitro interactions of Famotidine (FT) and Tapentadol hydrochloride (TAP) with bovine serum
albumin (BSA) have been studied by fluorescence emission spectroscopy under different conditions. Quenching
constants were determined using the Stern-Volmer equation. Two moles FT bound with 1 mole of BSA at 298 K and
3 mole FT bound with 1 mole of BSA at 308 K in presence of TAP. BSA was used for the study as it shows
approximately 76% sequence homology to human serum albumin (HSA).

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Issue

Vol. 15 No. 1 (2016)

Section

Articles