Formulation and in vitro assessment of eudragit L100 and eudragit S 100 based naproxen microspheres

Abstract

In the present study naproxen loaded microspheres were prepared by emulsification solvent
evaporation method in order to achieve targeted drug delivery. Eudragit L 100 and Eudragit S 100 were used as the
rate retardant polymers in the preparations. Thirteen formulations (F1-F13) were prepared using 22 factorial design by
changing the concentration of these two polymers. All the formulations were evaluated for product yield, drug
content, entrapment efficiency, particle size and drug release profiles. Highest drug content and entrapment efficiency
were found to be 30.17% (F4) and 91.86% (F8) respectively. The particle size was found to be 159.26-234.70 μm for
all formulations. In-vitro drug release studies were performed using USP type II (Paddle) apparatus for 8 hrs in pH
7.4 phosphate buffer. The maximum drug release after 8 hrs was found to be 60.19% for batch F4. The release
kinetics of all formulations were evaluated by using zero order, first order, Higuchi, Korsmeyer-Peppas, Kopcha and
Hixson Crowell model. Almost all formulations fitted best with the Kopcha kinetic model. The SEM study indicated
the spherical structure of the microspheres having rough surfaces.