Enhancement of dissolution profile of poorly water soluble loratadine by solid dispersion technique

Abstract

This study was carried out to improve the dissolution properties of loratadine by solid dispersion
technique. A series of solid dispersions of loratadine in PVP K-30 (1:1, 1:3 and 1:5) were prepared by kneading
technique. The prepared solid dispersions were characterized by various physicochemical properties (fourier
transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy) and the dissolution
characteristics were compared with loratadine and the physical mixtures of loratadine. It was revealed from the
physicochemical analyses that there was a good compatibility between drug and carrier. On the other hand, the drug
release from the prepared binary solid dispersions was significantly enhanced in comparison to both drug alone and
the physical mixtures. Finally solid dispersion of loratadine: PVP K-30 prepared as 1:5 ratio was found to be
described by non-Fickian release mechanism and was selected as the best formulation in this study.