Design and development of bi-layered sustained release azithromycin tablets

Authors

  • Muhammad Rashedul Islam
  • Md. Mizanur Rahman Moghal
  • F.M. Shah Noman Ul Bari
  • Elias Al Mamun

Keywords:

Azithromycin, bilayer tablet, HPMC, Carbopol, sustained release.

Abstract

The objective of the current study was to develop a bilayer tablet of Azithromycin containing both
immediate and sustained layer and evaluate the effect of formulation variables on drug release. Thirty different
formulations (F-1 to F-30) were prepared by direct compression. When the fraction of polymer was increased from
5.55% to 10%, the rate of drug release was found to be slower. Maximum release of Azithromycin was from F-11
(within 8 hours), which contained 50 mg (5.55%) of HPMC 50 cps. Slowest release was observed from F-30
containing 90 mg (10%) of Carbopol 974 P. The IR spectral analysis revealed that all rate regarding agents and
excipients used in this study are compatible with the active Azithromycin.

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Issue

Vol. 15 No. 2 (2016)

Section

Articles