Chemical and Biological Investigations of Cerbera odollam Gaertn

Authors

  • Monica Sharfin Rahman
  • Sharfin Rahman
  • Choudhury Mahmood Hasan
  • Monira Ahsan
  • Mohammad Mehedi Masud

Keywords:

Cerbera odollam, triticusterol, antioxidant activity, cytotoxicity, antimicrobial activity, thrombolytic activity, membrane stabilizing activity.

Abstract

The present article describes the isolation and characterization of secondary metabolites from the
leaves of Cerbera odollam as well as bioactivities of the crude methanolic extract and its petroleum ether (PE),
carbon tetrachloride (CTC), chloroform (CF) and aqueous (AQ) soluble fractions. In this investigation, successive
chromatographic separation and purification yielded β-amyrin (CO-01), lupeol (CO-02), β-sitostenone (CO-03) and
triticusterol (CO-04). The study also indicated the antioxidant, cytotoxic, antimicrobial, membrane stabilizing
activities and poor thrombolytic activities. Thus, the present study endeavors to provide scientific basis to establish
Cerbera odollam as a potential medicinal plant.

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Issue

Vol. 16 No. 2 (2017)

Section

Articles