Synthesis and Antioxidant Activity of Some Novel Benzimidazole Derivatives

Authors

  • Nilima Karmaker
  • Dilshad Noor Lira
  • Biplab Kumar Das
  • Uttom Kumar
  • Abu Shara Shamsur Rouf

Keywords:

Benzimidazole, synthesis, antioxidant activity, DPPH, BHT

Abstract

series of 2-substituted-5-methylbenzimidazole derivatives (3a-e) were synthesized by reacting
4-methyl-1,2-phenylenediamine (1) with a number of p-substituted benzaldehydes (2a-e) in moderate yields (25.51-
40.21%). The synthesized compounds (3a-e) were characterized by spectroscopic data and were evaluated for
antioxidant activity using DPPH free radical scavenging assay. The compounds showed significant antioxidant
activity having IC50 value of 1.054-19.05 μg/ml as compared to the standard BHT (26.96 μg/ml).

Downloads

Issue

Vol. 16 No. 2 (2017)

Section

Articles