Impact Assessment of Different Polymers on Physicochemical Properties of Ibuprofen Loaded Solid Dispersions

Abstract

In the present study, solid dispersions of ibuprofen were prepared to improve aqueous solubility of
ibuprofen. A series of formulations were prepared where PEG 6000 with polymers named PVP K30, cross PVP,
poloxamer 237, HPMC ASLF, pregelatinized starch, Na-CMC, Eudragit L100, and kollidon IR were used in
different ratios. Among 41 formulations, solid dispersions of ibuprofen in PEG 6000 with each of PVP K30,
poloxamer 237, and Na-CMC at ratio of 2:9:7 revealed improved solubility of 952.73 ± 1.31, 878.18 ± 0.97, and
1263.64 ± 1.58 μg/ml, respectively. The physicochemical properties of these preparations were ascertained by FTIR,
SEM, DSC, and particle size analyses. FTIR spectrum showed absence of chemical interactions and physical
compatibilities between ibuprofen and polymers were confirmed by DSC. Disappearance of individual surface
properties in solid dispersions were revealed by SEM studies, which indicated the formation of effective preparations.
On the other hand, particle size analysis showed reduction in particle size of ibuprofen from solid dispersions that
demonstrated solubility enhancement of ibuprofen. The above studies suggested that solid dispersions of ibuprofen in
PEG 6000 at ratios of 2:9:7 with each of PVP K30, poloxamer 237, and Na-CMC were found to be effective to
improve aqueous solubility.