Characterization and Disintegrant Potential of Phosphorylated Tiger Nut (Cyperus esculentus) Starch in Immediate Release Ibuprofen Tablet Formulation
Keywords:
Cyperus esculentus starch, phosphorylation, modifiedstarch, disintegrant, ibuprofen tablet.Abstract
The study was aimed at evaluating the physicochemical properties of phosphorylated
tiger nut starch (TNP) and its disintegrant properties in immediate release ibuprofen tablets. Native tiger
nut starch (TNS) was modified by phosphorylation with disodium hydrogen orthophosphate at 130oC
and its physicochemical properties were evaluated. Ibuprofen tablets were formulated with TNP and
sodium starch glycolate (SSG) at concentrations of 5.0, 7.5, 10.0 and 15.0% as disintegrants.
Phosphorylation of TNS led to improved flow properties and swelling and hydration capacities among
other changes in the physicochemical properties. TNP had comparable properties with SSG. FTIR study
confirmed modification and also showed that TNP is compatible with ibuprofen powder. Ibuprofen
tablets produced with TNP as disintegrant had acceptable tablet properties comparable to those produced
with SSG. The disintegrant potential improved with increased concentration of TNP. The results
indicate that TNP has a promising disintegrant potential in tablet formulations.
