Syntheses, Characterization and Biological Evaluation of a Series of 2-Phenylamino-5-(2-Chlorophenyl)- 1,3,4-Oxadiazole Derivatives

Abstract

Electrochemical synthesis of 2-phenylamino-5-(2-chlorophenyl)-1,3,4-oxadiazoles have been carried
out in good yields at platinum electrode through the electrochemical oxidation of acyl thiosemicarbazide at room
temperature in acetic acid. Two platinum electrodes in the form of square plates were used as working as well as
counter electrode and saturated calomel electrode was used as reference electrode. The structure of the compounds was
confirmed by IR, NMR, mass spectral and elemental analyses. The antibacterial activity of the derivatives was also
assessed and compared with data against a series of Gram-positive Klebsiella pneumoniae, Escherichia coli and Gramnegative
bacteria Streptococcus aureus and Bascillus subtilis. The antifungal activity was assessed against the fungal
strain Aspergillus niger, Crysosporium pannical, Pellicularia solmanicolor and Candida albicans and compared
against the standard antifungal drug Griesvofulvin.