Evaluation of Antioxidant and Cytotoxic Activities of Aerial Parts of Adiantum capillus-veneris L. Growing in Bangladesh
Keywords:
Antioxidant, cytotoxicity, Adiantum capillus-veneris L., fractionation, bioactivity.Abstract
The present study evaluated the antioxidant and cytotoxic activities of methanolic extract of aerial
parts of Adiantum capillus-veneris L. and its different solvent fractions. The in vitro antioxidant activity was
assessed by using 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals. The analysis revealed that ethyl acetate soluble
fraction had the highest DPPH radicals scavenging property with IC50 value of 1.05 μg/ml as compared to positive
control ascorbic acid (IC50 = 1.34 μg/ml). In addition, ex vivo cytotoxicity assay of A. capillus-veneris L. extract and
its different fractions were performed against HELA cells line where 5-Fluorouracil was used as positive control.
The result demonstrated that ethyl acetate and n-hexane soluble fractions showed prominent cytotoxicity with IC50
value of 5.68 μg/ml and 17.15 μg/ml, respectively. The study affirmed that superior antioxidant and cytotoxic
activities were shown by ethyl acetate soluble fraction of methanolic extract of aerial parts of A. capillus-veneris L.
growing in Bangladesh which indicate the presence of bioactive phytoconstituents in the extractives.
