Study of Release-Retardant Polymers in Formulation Development of Cinnarizine-HCl Sustained-release Oral Suspension Using Raft Technology

Abstract

The main objective of this research was to develop a sustained-release suspension of cinnarizine
hydrochloride using raft-forming technique. This innovative approach has been utilized to formulate a series of
suspension formulations using hydroxypropyl cellulose (HPC) as a release-retardant polymeric agent. Cinnarizine
sustained-release suspensions were prepared by physical mixing method with varying concentrations and
combinations of HPC, sodium citrate, sodium saccharin, calcium carbonate, sodium alginate, methyl
hydroxybenzoate and propyl hydroxybenzoate. The formulations were subjected for determination of floating time,
floating lag time, weight of the raft, physical appearance and in-vitro dissolution. The dissolution was conducted
through USP apparatus 2 (paddle type) in 0.1N hydrochloric acid medium having pH 1.2. The key findings of the
study demonstrate that a stable sustained-release suspension of cinnarizine can be formulated using raft-forming
approach for increased bioavailability and patient-convenience.