Nickel(II)-Complex of Ceftibuten Dihydrate: Synthesis, Characterization and Thermal Study

Abstract

Ceftibuten dihydrate is a semisynthetic, orally administered, third generation cephalosporin antibiotic
which is effective against most of the pathogens causing infections in the respiratory tract. Complexation of
ceftibuten dehydrate (Ligand, L) was performed with hydrated Ni(II) salt (Metal, M) in the ratio of 2:1 (L:M) in
aqueous medium at 90 oC. The metal complex was then characterized by spectral techniques and thermal analyses.
The FT-IR spectral data of metal complex suggested the monodentate bonding of metal ion to carboxylate group.
Spectral evidence also supported the formation of five-membered ring via coordination of metal ion to β-lactam
nitrogen and carboxylate group of parent drug. Thermal behavior of ligand and complex were studied. Thus, thermoanalytical
(DSC and TGA) results also supported the formation of new metal complex, indicating the successful
interaction of metal ion to ligand.