Immunoglobulin levels in manic patients

Abstract

The aim of this study was to determine the serum immunoglobulin concentration in both manic
patients and in healthy volunteers. The study was conducted with 30 manic patients (24 males and 6 females, aged
55.4 ± 13.0 years); age and gender-matched, control subjects were enrolled. An enzyme-linked immunosorbent assay
(ELISA) was employed to analyze the serum immunoglobulin concentrations. IgG level was found to be 18.22±6.42
g/L in the manic patients, while it was 16.05 ± 3.45 g/l in the cohort controls (p=0.487). IgM and IgA concentrations
were 6.025 ± 1.07 g/l and 1.41 ± 0.51 g/l in the manic patients, whereas those were 5.73 ± 1.63 g/l (p=0.688) and
0.837 ± 0.36 g/l (p=0.034) respectively in controls. From the results it was found that only the serum concentration of
IgA was increased significantly (p=0.034) in manic patients while the concentrations of IgG and IgM remained
unchanged. In many psychiatric disorders, immunoglobulin level has been found to be changed significantly. This
study reveals that the concentration of IgA in manic patients increased significantly (p=0.034) which usually happens
in case of many psychiatric patients. Further studies are suggested with larger population to find out the correlation
between immunoglobulin level and degree of disorder and possibility of using as a diagnostic tool for the
identification of this disease.