QSAR Optimization of Benzofuran and Benzothiophene Sulfono Biphenyl as Potent PTPase-1B Inhibitors

Abstract

Insulin resistance is associated with a defect in protein tyrosine phosphorylation in the insulin signal
transduction cascade. Protein tyrosine phosphatase (PTPase) enzyme dephosphorylates the active form of insulin
receptor and thus attenuates its tyrosine kinase activity, therefore the need of potent PTPase inhibitor is there with
that intention the Quantitative structure-activity relationship QSAR was performed. QSAR has been established on a
series of compounds of novel sulfono biphenyl analogs using SYSTAT (Version 7.0) software, for their PTPase-1B
inhibitor activity, in order to understand the essential structural requirement for binding with the receptor. Among
several 2D QSAR models, one for a series was selected on the basis of high correlation coefficient, least standard
deviation, & high value of significance for maximum no. of subject was considered. The interpreted data signify the
essentiality of Benzofuran ring in the designing of the new PTPase -1B inhibitors and any substitution on the
biphenyl and sulfonyl phenyl is going to decrease its activity.