Antineoplastic Activity of Bis-tyrosinediaqua Ni(II) Against Ehrlich Ascites Carcinoma

Abstract

In order to find out new compounds having antineoplastic activity, bis-tyrosine diaqua nickel (II)
complex was synthesized and characterized. The antineoplastic activity of the compound was judged by measuring
inhibition of tumour growth and enhancement of survival time of EAC cell bearing mice. In addition its effects on
haematological parameters and serum alkaline phosphatase activity of both normal and EAC bearing mice were also
studied. The test compound significantly inhibited the tumour growth and increased life span of tumour bearing mice
at dose 10 mg/kg i.p. The treatment also recovered the perturbed haematological parameters as well as the serum
alkaline phosphatase activity towards normal. The host toxicity of the test compound was found to be negligible. The
compound can be considered as an effective antineoplastic agent.