Swelling and Erosion Modulation of Sterculia Foetida Gum Through Real Time Texture Probing

Abstract

In the present investigation an attempt has been made to increase therapeutic efficacy, reduce
frequency of administration and improve patient compliance by developing controlled release matrix tablets of
diltiazem hydrochloride. Diltiazem hydrochloride was formulated as oral controlled release matrix tablets by using
sterculia foetida gum. SFG fines were characterized with scanning electron microscopy. The purpose of this study
was to optimize release profile of the highly water soluble drug from SFG matrix by using water soluble and
swellable excipients like lactose and microcrystalline cellulose respectively. Tablets were prepared by direct
compression, and their swelling behavior in presence of these excipients was assessed with the help of a Texture
Analyzer. Dissolution assessment was performed using USP 26 apparatus 2 modified by insertion of a mesh to
prevent sticking of the tablets to the bottom of vessel and allow them to swell three dimensionally. The
interdependence of swelling front movement in relation to excipients type and progression of drug release are
explained. It was concluded that unlike in conventional dosage forms insertion of excipients in hydrophilic
controlled release tablets containing a water soluble drug gave the finger print information of drug release profile. In
vitro drug release from these matrices was characterized and confirmed with the help of real time texture probing.
Results indicated that it is possible to achieve desired modulation in the drug release profile by inclusion of lactose
and microcrystalline cellulose.