Effects of Plastic and Acrylate Polymers on the Release Profile of Ambroxol Hydrochloride Controlled Release Pellets

Authors

  • Ishtiaq Ahmed
  • Monzurul Amin Roni
  • Golam Kibria Kibria
  • Muhammad Rashedul Islam Rashedul Islam
  • Md Habibur Rahman Habibur Rahman

Keywords:

Aqueous coating, Eudragit® NE 30D, Kollicoat® SR 30D, release kinetics, pellets, extrusionspheronization

Abstract

The effects of Ammonio Methacrylate copolymer dispersion (Eudragit® NE 30 D) and Polyvinyl
Acetate dispersion (Kollicoat® SR 30 D) are compared on the in vitro release of Ambroxol Hydrochloride from
coated pellets in the current study. The nuclei pellets were manufactured by Extrusion-Spheronization with the drug,
microcrystalline cellulose, lactose, maize starch, and hydroxypropyl methylcellulose followed by fluid bed coating.
Dissolution study of coated pellets was performed with USP Type-II apparatus in acidic (0.1N HCl for 1 h) and
buffer (phosphate buffer, pH 6.8 for 11 h) media to simulate gastrointestinal environment. The release profile of drug
from two types of polymers were distinct and drug release was sustained longer by Polyvinyl Acetate film than
Acrylate polymer.

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Issue

Vol. 7 No. 2 (2008)

Section

Articles