Synthesis and Biological Activities of 2-Substituted Benzimidazole-Metal Complexes

Authors

  • Md. Afzal Azam
  • B. R. P. Kumar
  • R. Mazumdar
  • B. Suresh

Keywords:

Cu(II) complexes, Co(II) complexes, Benzimidazoles, Antitumor activity.

Abstract

A series of copper(II) and cobalt(II) coordination compounds with 2-substituted benzimidazole
derived monodentate and bidentate ligands have been prepared and characterized by microanalysis, IR and UV-Vis
spectroscopy. Synthesized metal complexes have been screened for their in vitro antioxidant and antitumor
activity. The complex 4a showed significant nitric oxide free radical scavenging activity (IC50 65μg/ml), while 3i
and 3g showed potent superoxide dismutase activity with IC50 of 0.26 and 0.28 μM respectively. In vitro
cytotoxicity study with human breast MCF-7 and CNS SF 268 cancer cell lines showed that the most active 2-
benzyl-1H-benzimidazole Cu(II) complex 3a inhibited the growth of cancer cells at 20 μM concentration.

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Issue

Vol. 8 No. 2 (2009)

Section

Articles