Effect of Cellulosic and Polymethacrylic Polymers on Drug Content, Particle Morphology, and Carbamazepine Release Profiles from Sustained Release Ethyl Cellulose Microspheres
Keywords:
Carbamazepine, Ethyl Cellulose, Sustained release microspheres, Emulsion-Solvent Evaporation Technique.Abstract
Emulsion-solvent evaporation technique was used to prepare Carbamazepine (CBZ) loaded Ethyl
Cellulose (EC) microspheres. Cellulosic polymers (HPMC 4.5 cps, 15 cps) and polymethacrylic polymers (Eudragit
E100, Eudragit RL PO, Eudragit RS PO) were added with EC at 10% (w/w) of EC. The effect of these polymers on
drug content, particle size, and CBZ release rate were evaluated. The CBZ encapsulation efficiency and the drug
content varied from 85% to 95% and from 42% to 45% (w/w), respectively. The mean particle diameter varied from
460 to 730 μm. In vitro release study for 8 hours was conducted in 1% (w/v) sodium dodecyl sulfate solution. All the
polymers reduced the release of CBZ and a statistically significant variation in release rate was observed from
polymer to polymer.
