Synthesis and Antimicrobial Screening of Three Triazole Derivatives

Abstract

Due to the medicinal importance of triazole derivatives, the antimicrobial property of three synthesized
triazole derivatives were screened in vitro against some Gram positive and Gram negative pathogenic bacteria and
some pathogenic fungi. In this study, three compounds 2-(5-mercapto-4-phenyl-4H-[1,2,4] triazole-3-yl]-cyclohexa-
1,5-dienol (S1), 2-[5-mercapto-4-(2-mercapto-phenyl)-4H- [1,2,4] triazole-3-yl]-phenol (S2) and 4-[3-(2-hydroxyphenyl)-
5-mercapto-[1,2,4] triazole-4-yl]-benzene sulfonamide (S3) have been synthesized. The minimum inhibitory
concentration (MIC) and the minimum bactericidal concentration (MBC) were assessed by serial dilution technique.
The compounds showed moderate antimicrobial activity against all the tested organisms and the results are
comparable to standard antibiotic kanamycin. The MIC values of the compounds were found to be in the range of
16~64μg/ml. The low MIC and MBC values and high sensitivity of pathogenic microorganisms to the compounds led
to conclude that the triazole derivatives have potential antimicrobial properties.