Antimicrobial, Antioxidant and Cytotoxic Activities of Glochidion multiloculare (Roxb. ex Willd.) Müll. Arg. (Euphorbiaceae)

Authors

  • A.T.M. Zafrul Azam
  • Abdullah Al Hasan
  • Md. Gias Uddin
  • Mohammad Mehedi Masud
  • Choudhury Mahmood Hasan

Keywords:

Glochidion, antimicrobial, brine shrimp lethality bioassay, total phenolic content, free radical scavenging.

Abstract

The methanol extract (ME) of the powdered bark of Glochidion multiloculare and its six vacuum
liquid chromatographic (VLC) fractions (Fa-f) were investigated for antimicrobial, cytotoxic and antioxidant activities.
Only fractions Fc and Fd showed mild antimicrobial activity. Significant free radical (DPPH) scavenging activity was
found in Ff (IC50 value = 9.27±0.117 μg/ml). The total phenolic content was measured involving Folin-Ciocalteu
reagent and it was the highest in fraction Fe (187.00±1.74 mg of GAE/gm of sample). Cytotoxicity (LC50) by brine
shrimp lethality bioassay was found to be significant for Fb (0.023±0.001 μg/ml), Fc (0.3±0.01 μg/ml) and Fd
(0.117±0.0015 μg/ml).

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Issue

Vol. 11 No. 2 (2012)

Section

Articles