Carvedilol-β-cyclodextrin Systems: Preparation, Characterization and in vitro Evaluation

Abstract

The purpose of this study was to improve the solubility and dissolution rate of carvedilol by forming a
complex with β-cyclodextrin. Phase solubility diagrams revealed increase in solubility of the drug upon cyclodextrin
addition, showing AN type curve. Complexation of carvedilol was carried out with β-cyclodextrin by physical mixing,
kneading and co-precipitation method. The prepared complexes and physical mixture were characterized by Fourier
transform infra red spectroscopy, differential scanning calorimetry, powder X-ray diffractometry and inclusion
efficiency. It was also observed that the complexes exhibit higher dissolution rates than the pure drug and physical
mixture. Among all carvedilol-cyclodextrin complexes, inclusion complex (1:5) prepared by co-precipitation method
showed better release.