The in vitro Antimycobacterial Investigation of Some Basic meta-/para-Alkoxyphenylcarbamic Esters Bearing 4-(4-Fluoro/2-methoxyphenyl)piperazin-1-yl Fragment

Abstract

Following our previous systematic research with ortho-/meta-/para-alkoxyphenylcarbamic acid esters
as antimycobacterially active compounds, the set of the derivatives containing meta-/paraalkoxyphenylcarbamoyloxy
and 4-(4-fluorophenyl/2-methoxyphenyl)piperazin-1-yl moieties were tested for their in
vitro activity against Mycobacterium tuberculosis CNCTC My 331/88 as well as against potential pathogenic strains
of M. kansasii CNCTC My 235/80, M. avium CNCTC My 330/88 and M. kansasii 6 509/96 by applying the
micromethod for the determination of the minimum inhibitory concentration (MIC). In terms of estimated MIC
readouts, the advantage of the molecules under study has been the activity against Mycobacterium tuberculosis.