In vivo Pharmacological Investigation of Leaf of Polygonum hydropiper (L.)

Abstract

The present study was planned to evaluate the anti-nociceptive, gastro intestinal motility, anti-pyretic
and acute toxicity studies of leaf extract of Polygonum hydropiper leaves in albino mice following oral
administration. The results showed that the anti-nociceptive activity in the scale of ethanol > n-hexane > petroleum
ether > chloroform > methanol extract showed a significant result compared to diclofenac sodium. Chloroform
extract showed significant results on gastro intestinal motility test. Ethanol & chloroform extracts showed
considerable reduction of temperature at higher doses within 1st hour on yeast induced pyrexia in albino mice.
Highest dose introduced as 1000, 2000 & 4000 mg/kg body weight of each extracts in acute toxicity test did not
shown any sign of toxicity in albino mice in one week observation.