Improvement of In vitro Release of Glibenclamide Using Cyclodextrin Inclusion Complexation

Authors

  • Neelkant Prasad
  • Navneet Garud
  • Akanksha Garud

Keywords:

Glibenclamide, ?-cyclodextrin, Inclusion complex, Neutralization method, Co-precipitation.

Abstract

The present study aimed to improve the aqueous solubility of the oral hypoglycemic agent,
glibenclamide (GLI), so as to improve its oral absorption, and hence bioavailability after oral administration. This
was accomplished by complex formation between GLI and β-cyclodextrin (β-CD). The study involves the
preparation of the inclusion complexes using different techniques. Differential Scanning Calorimetry (DSC) and XRay
Diffractometry (XRD) results confirmed the complex formation between GLI and β-CD. The solubility increase
of GLI was due to 1:1 complex formation. The dissolution rate of GLI from the complex prepared by neutralization
method was more rapid as compared to other methods used.

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Issue

Vol. 13 No. 1 (2014)

Section

Articles