Analgesic and Anti-diarrhoeal Activities of Lagerstroemia speciosa Roots in Experimental Animal Model

Abstract

The methanolic crude extract of Lagerstroemia speciosa roots was investigated for its possibleanalgesic and anti-diarrhoeal activities in experimental animal model. Phytochemical screening of the methanolicextract of L. speciosa roots showed the presence of alkaloids, flavonoids, saponins, tannins and reducing sugar. Inacute toxicity study, no mortality or toxic reaction was recorded in animal model after administration of the L.speciosa roots extract. Analgesic activity was evaluated by using acetic acid induced writhing inhibition method inSwiss albino mice. In peripheral method of anti-nociception, the methanolic crude extract of L. speciosa roots showedsignificant analgesic activity. At the dose of 200 and 400 mg/kg body weight, the extract produced 35.38% and53.85% (P<0.001) of writhing inhibition, respectively compared to standard diclofenac sodium (70.77% inhibition).The extract had also anti-diarrhoeal activity in castor oil induced method and inhibited the mean number ofdefecation by 32.75% (P<0.01) and 51.72 % (P<0.001) at the dose of 200The methanolic crude extract of Lagerstroemia speciosa roots was investigated for its possibleanalgesic and anti-diarrhoeal activities in experimental animal model. Phytochemical screening of the methanolicextract of L. speciosa roots showed the presence of alkaloids, flavonoids, saponins, tannins and reducing sugar. Inacute toxicity study, no mortality or toxic reaction was recorded in animal model after administration of the L.speciosa roots extract. Analgesic activity was evaluated by using acetic acid induced writhing inhibition method inSwiss albino mice. In peripheral method of anti-nociception, the methanolic crude extract of L. speciosa roots showedsignificant analgesic activity. At the dose of 200 and 400 mg/kg body weight, the extract produced 35.38% and53.85% (P<0.001) of writhing inhibition, respectively compared to standard diclofenac sodium (70.77% inhibition).The extract had also anti-diarrhoeal activity in castor oil induced method and inhibited the mean number ofdefecation by 32.75% (P<0.01) and 51.72 % (P<0.001) at the dose of 200