Preliminary Phytochemical Screenings and Pharmacological Activities of Blumea lacera (Burn.f.) DC.

Abstract

The methanol extract of the whole plant of Blumea lacera (Burn.f.) DC. (BLME) has been subjected
to preliminary screenings for phytoconstituents and antipyretic, analgesic and anti-inflammatory activities.
Antipyretic activity was assessed by the yeast-induced hyperthermia in mice. The analgesic property was evaluated
by formalin-induced writhing test. Acetyl salicylic acid (ASA) was used as standard for in-vitro anti-inflammatory
activity test. In yeast-induced pyrexia, the crude extract demonstrated a significant (p=0.05) reduction in body
temperature of mice after elevation by the administration of yeast. These effects were pronounced at the 2nd and 3rd h
of post-treatment with the extract. BLME exhibited a dose-dependent analgesic activity with 39.13% and 56.52%
protection at 200-and 400-mg/kg, b.w., respectively as compared to 76.09% revealed by the standard diclofenac
sodium. In the anti-inflammatory test, the crude extract at 400 μg/ml displayed 62.40% inhibition of protein
denaturation whereas standard acetyl salicylic acid exhibited 76.74% inhibition. Results of the preliminary
phytochemical screenings demonstrated the presence of alkaloids, flavonoids and triterpenoids in the extract.