Preparation and Evaluation of Sustained Release Venlafaxine HCl Microspheres

Abstract

The aim of this study was to formulate and evaluate sustained release microsphere of Venlafaxine HCl
(VF-HCl). It has many side effects with a half life around 5 hr. To reduce the adverse actions due to burst effect a
sustained release (SR) Eudragit RS-100 microspheres embedded VF-HCl was formulated. The VF-HCl microspheres
were prepared by oil in oil (O/O) solvent evaporation method. Drug and Polymer interaction for formulated SR
Eudragit RS-100 microsphere embedded on VF-HCl was characterized by FT-IR and X-RD studie. The result
showed that there is no interaction between the drug and polymer. Surface morphology of formulation carried out by
FE-SEM … showed good spherical geometry and uniformity in size and shape. It can be concluded that the
formulated VF-HCl microspheres using widely accepted O/O method and polymer were capable for exhibiting
sustained release formulation with decreasing dosing frequency thereby minimizing the occurrence of side effects
with improved bioavailability.