Gastroentero-histopathology Studies of Synthesized Naproxen Esters in Young Healthy Sprague-Dawley Rat Model

Abstract

Naproxen and its synthesized esters namely naproxen methyl ester, C15H16O3 (compound 1), ethyl
ester, C16H17O3 (compound 2) and isopropyl ester, C17H20O3 (compound 3) were subjected to NSAID induced
gastro-ulcergenecity studies on young, healthy male rat model. Rats (Rattus novergicus: Sprague-Dawley strain)
of 2-months old weighing 95–105 g were administered with naproxen (10 mg/kg b.w.) compound 1 (10.609
mg/kg b.w.), compound 2 (11.217 mg/kg b.w.) and compound 3 (11.826 mg/kg b.w.) twice daily for 4.5 days. The
naproxen esters appeared to induce significantly less GI injury and bleeding both in microscopic and macroscopic
examinations. This study can be a basis of reference for further acute, chronic or subchronic toxicity studies in
various in-vivo models.