Neoandrographolide Isolated from Leaves of Adhatoda vasica Nees

Abstract

Neoandrographolide was isolated from the ethylacetate soluble fraction of the ethanol extract of the fresh leaves of Adhatoda vasica (Family: Acanthaceae). The crude extracts of hexane, ethylacetate and butanol soluble fractions of ethanol extract were subjected to antimicrobial screening and brine shrimp lethality bioassay. The ethylacetate crude extract exhibited moderate antimicrobial activity against most of the test organisms and also showed significant cytotoxicity having LC₅₀ 0.61 µg/ml.