New Diarylheptanoid from Garuga pinnata Roxb

Abstract

9´-Desmethylgaruganin I has been isolated from the dichloromethane extract of the stem bark ofGaruga pinnata Roxb. The crude extract was screened for antimicrobial activity against a wide range of gram-positive and gram-negative bacteria and fungi by disc diffusion method and cytotoxicity by brine shrimp lethality bioassay. The dichloromethane extract showed moderate inhibitory activity to microbial growth and weak cytotoxicity having LC₉₀ 25.703μg-mL^–1