Benzylation of p-Chlorophenol: A Statistical Study

Abstract

A statistical model has been developed for the benzylation of p-chlorophenol with benzyl alcohol in the presence of sulphuric acid as
catalyst using Yates pattern experimental design. A set of trials was planned according to a 3 factor 2-level Yates pattern experimental
design with 2 replicates and the center point trial with 4 replicates. The critical response was the yield of 2-benzyl-4-chlorophenol. Main
effects as well as two-factor interaction effect were statistically significant. A polynomial model was developed and the adequacy of the
suggested model was checked up.