Chemical and Biological Investigations on the Leaves of Jatropha gossypefolia

Abstract

Two compounds were isolated from the petroleum ether crude extract of the dried leaves from Jatropha gossypefolia. Based on the spectral
evidence, their structures were determined to be β-sitosterol-3-O-β-D-glucopyranoside and stigmasterol. The crude extract of petroleum
ether, dichloromethane, carbon-tetrachloride, methanol extract were screened for their antimicrobial activity against a wide range of grampositive
bacteria, gram-negative bacteria and fungi by disc diffusion method and brine shrimp lethality bioassay. The crude
dichloromethane extract showed mild to moderate inhibitory activity to microbial growth while the column fraction F-8 showed strongest
cytotoxicity having LC50 6.31 μg/ml.