Cyclic Voltammetric Study of the Interaction of Biologically Important Metal Ion with Proton Pump Inhibitors

Abstract

Electrochemical studies on the interaction of Fe(III) with proton pump inhibitors (PPIs) (omeprazole, pantoprazole, esomeprazole and
rabeprazole) in acetate buffer solution were carried out at gassy carbon electrode (GCE) at various pH (3.5, 4.0 and 4.5). In presence of
omeprazole (Ome), the anodic and cathodic peak current for Fe(III) decreased in comparison to solely Fe(III). However, in some cases both
the peaks were almost disappeared. Moreover, anodic and cathodic peaks shifted significantly towards negative potential. This is an indication
that a strong interaction occurred between Fe(III) and Ome. The maximum interaction is found at 1:2 molar ratio of Fe(III) and Ome at above
mentioned pH. The electrochemical interaction of Fe(III) and other PPIs was found as identical with the behavior of Ome. The electrochemical
study of the interactions between metal ions and PPIs would provide important information for the technological application of PPIs in human
body.