Determination of piroctone olamine (Octopirox) in bulk by UV spectrophotometric method

Lyudmyla M. Antypenko, Vitaliy A. Solodovnyk


A simple and low-cost UV-spectrophotometric method has been developed and validated for the
quantification of Octopirox in bulk. The linearity was found at 307 ± 1 nm in 10-50 μg/ml solution of ethanol-water
(1:3, v:v) with r2 = 0.99. The limit of detection was found to be 1.18 μg/ml, while the limit of quantification was 3.58
μg/ml. The method was validated for linearity, accuracy, precision, range, ruggedness and robustness.


Octopirox, validation, UV-spectrophotometry

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The Dhaka University Journal of Pharmaceutical Sciences
ISSN 1816-1820 (Print) 1816-1839 (Online)